SHTP

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Secondary hyperparathyroidism (SHPT, or secondary hyperparathyroidism) is a chronic compensatory clinical condition in which the parathyroid glands are chronically stimulated by low blood calcium, low blood magnesium, or high blood phosphorus and secrete excessive amounts of PTH in order to raise blood calcium, blood magnesium, and lower blood phosphorus in the presence of chronic renal insufficiency, intestinal malabsorption syndrome, Fanconi's syndrome, and renal tubular acidosis, vitamin D deficiency or resistance, as well as in the presence of pregnancy and lactation. Phosphorus is a chronic compensatory clinical manifestation of prolonged parathyroid hyperplasia that eventually leads to the formation of functionally autonomous adenomas. We have established a stable model of SHPT due to different triggers, which is suitable for preclinical studies of drugs for the treatment of SHPT and for the evaluation of new drugs. If you have a project need and experience more of our professional services, please contact us.

Disease Name	Model name	Species of animals
Disease Name	Model name	Mouse	Rat	Hamster	Guinea pig	Ferret	Rabbit	Cat	Dog	Pig	Non-human primate
SHTP	SHPT induced by 5/6 nephrectomy model		√
SHTP	SHPT induced by adenine feed in chronic renal failure uremia model		√