Diffuse intravascular coagulation

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Diffuse intravascular coagulation

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  • Diffuse intravascular coagulation is a clinical syndrome characterized by bleeding and microcirculatory failure due to damage to the microvascular system by pathogenic factors on the basis of many diseases, resulting in coagulation activation, systemic microvascular thrombosis, massive depletion of coagulation factors and secondary hyperfibrinolysis. Disseminated intravascular coagulation is not an independent disease, but an intermediate link in the complex pathological process of many diseases. According to the speed of occurrence of disseminated intravascular coagulation, it is divided into acute, subacute, and chronic types; according to the compensation of disseminated intravascular coagulation, it can be divided into loss of compensation, compensation, and overcompensation. We have established a stable lipopolysaccharide (LPS)-induced diffuse intravascular coagulation model, which is suitable for the study of drugs with preclinical diffuse intravascular coagulation and the evaluation of new drugs. If you have a project need and experience more of our professional services, please contact us.
Disease NameModel nameSpecies of animals
MouseRatHamsterGuinea pigFerretRabbitCatDogPigNon-human primate
Diffuse intravascular coagulationA model of lipopolysaccharide (LPS)-induced diffuse intravascular coagulation

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