Cough

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Cough is a common respiratory symptom caused by inflammation, foreign body, physical or chemical irritation of the trachea, bronchial mucosa or pleura, which is manifested first by the closure of the vocal folds, contraction of the respiratory muscles, and an increase in the intrapulmonary pressure, followed by the opening of the vocal folds, and the ejection of air from the lungs, usually accompanied by sound. Coughing has a protective effect in removing foreign bodies and secretions from the respiratory tract. However, if the cough does not stop and turns from acute to chronic, it often causes great pain to the patient, such as chest tightness, itchy throat and wheezing. Cough may be accompanied by coughing up sputum. We have established a stable citric acid + histamine-induced cough model in guinea pigs, which is suitable for the study of drugs for preclinical cough and the evaluation of new drugs. If you have project needs and experience more of our professional services, please contact us.

Disease Name	Model name	Species of animals
Disease Name	Model name	Mouse	Rat	Hamster	Guinea pig	Ferret	Rabbit	Cat	Dog	Pig	Non-human primate
Cough	Citric acid + histamine-induced cough model in guinea pigs				√